Clinical Outcomes

Key Data:

  • Two-year outcomes data from GARFIELD-AF show that death is the most frequent adverse outcome for patients with AF
    • The highest rates of stroke/systemic embolism, major bleeding and death occurred during the first 4 months of follow-up and gradually diminished over time
    • Anticoagulation therapy was associated with a 35% lower risk of death
    • Strokes were not the most frequent cause of mortality, accounting for less than 10% of all known causes of death
    • Mortality rate due to cardiovascular (CV) causes including fatal bleeds was 1.55 per 100 person-years. CV deaths were most frequently caused by CHF, sudden or unwitnessed death, ACS and ischaemic stroke
      • Strokes accounted for fewer than 10% of all known causes of death
    • Mortality rate due to non-CV causes was lower, at 1.37 per 100 person-years. Non-CV deaths were most frequently caused by malignancy, respiratory failure and infection/sepsis
    • Strokes were predominantly ischaemic and primary haemorrhagic strokes were very uncommon
    • Bleeding events most frequently occurred in the gastrointestinal tract (1.5% of the total registry population)

Key Publications:

Related Publications

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27 Jun 17

Global status

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Total patients 57,262
Recruitment Recruitment closed
Follow-up Ongoing
Study end: 2018

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To find out more about GARFIELD-AF, please contact the Thrombosis Research Institute

E: garfield@tri-london.ac.uk
T: 0203 198 9947